Mistaken concepts: the taste buds

OK, kids, we need to talk. No, you’re not in trouble. The people in trouble are health, anatomy, and psychology teachers who try to teach a specific concept that is WRONG.

Any guesses about what connects those teachers? No? Well, here’s the offending diagram.

Don’t believe images like this. EVER.

That, my lovelies, is a picture of a tongue. But see those cool segments that tell you what flavor is tasted by each segment of the tongue? They’re completely and totally unnecessary. Your tongue doesn’t work that way, despite what so many teachers and even college professors would have you believe.

No, don’t try to look all cute and happy, Mr. Boring. You’re on scientific trial here.

Let’s go back a bit to Harvard University circa 1901. A psychologist, Edwin G. Boring (more like Edwin G. Mistaken-Fact-Check) misinterprets data in a German paper, leading to the belief that each region of the tongue is specialized to taste exactly one of four basic flavors.

“OH! Cool!” he says, thinking this break-through will change the way we interact with food (or something).

Trust me, it didn’t.

Let’s fast forward to 1974, when Virginia Collins discovered that all tastes are distributed equally across the tongue. Case closed, right?

NOPE! People are STILL using the tongue map to explain taste buds in 2012!

Let’s expand your knowledge a bit, though. Why is this tongue map concept so incredibly insulting to the science of taste? Here’s three big reasons why!

Well, first off,  it is incorrect in the count of basic flavors. The map shows the four flavors (bitter, sour, salty, and sweet) that were known in 1901, but there are at least five that we know of now. The four that are on the map DO exist; the fifth wheel of taste we use at a wine and cheese party is actually one of the most important – umami. That’s the taste of savory things like meat and cheese, and was described as early as 1908, a mere seven years after Boring made his translational mistake.

Secondly, the map claims the receptors for each flavor only exist on the edges of the tongue, the very back, and the very tip. That leaves a HUGE bit of space that doesn’t really do much, right smack in the center… where most food hits the tongue.

Um. Science says, “Whoops?”

It’s an impractical model from the start, is what I’m trying to say.

Thirdly, our sense of taste is much more important in basic development and exploration than the map allows for. From the time we are born, we explore the world through all of our senses. Senses like sight don’t fully develop until we are between 6 and 18 months of age, but we make up for what we lack by using other senses, taste, in the case of infants.

Well, why is that particularly important, you ask? Because of chemistry. The basic correlation between chemistry and taste is that acids taste sour and bases taste bitter. The safest way of testing this is to taste a lemon, which is full of citric acid. It’s sour, right? Right.

Since things that are bitter are not necessarily desirable as food products, it’s very difficult to find them on market shelves. Egg whites and some crackers are the closest edible things you’ll find to basic foods.

Now, think back to childhood…. Do you think a baby would like something that tastes bitter? NO! That’s a natural response. It’s a safety precaution, too; bitter foods tend to contain deadly chemicals, like ammonia. According to the tongue map, those substances would have to hit the back of the tongue to be tasted, which probably means someone is going to have to call poison control because little Johnny has swallowed ammonia instead of spitting it back out because he tasted that bitterness immediately.

So, lesson of the day? Don’t think of the tongue as some city planner’s way of keeping the taste bud gangs from having turf wars. It’s much more accurate to think of it as a metro area, where everybody mixes and coexists while doing their jobs.

 

O’Connor, Anahad (November 10, 2008). “The Claim: The tongue is mapped into four areas of taste”. The New York Times.

Hänig, David (1901). “Zur Psychophysik des Geschmackssinnes”. Philosophische Studien 17: 576–623.

Wanjek, Christopher (August 29, 2006). “The Tongue Map: Tasteless Myth Debunked”. Livescience.com.

 

Image sources:

www.leavingbio.net

www.igs.net/~pballan

 

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  Timothy Durham was convicted of rape when a test showed his DNA genotype matched the DNA recovered from the crime scene. Eye witnesses testified that Durham was in a different state at the time of the incident, but he wasn’t exonerated from his 3000 year sentence until follow up DNA analysis showed that the preliminary forensic analysis used in the trial was misinterpreted (Thomas et al.). DNA testing serves an invaluable part in our criminal justice system, but it comes with complications and bias that can lead to wrongful convictions and misinformed juries.  

Background:

Forensic genetics aims to identify the origin of a biological sample. It can be traced back to Karl Landsteiner who discovered human ABO blood groups. With blood groups, suspects could be eliminated based on their blood type. For example, if a suspect had type A blood and there was type B blood left at the scene by the perpetrator, the investigators could rule out the suspect. Unfortunately, the reverse didn’t work. If the suspect and perpetrator both had the same blood type, it can’t be concluded that the suspect was guilty. Blood identifiers evolved into 8 distinct categories which improved the ability to eliminate suspects, but could only conclude that (if the system matched) it might be the perpetrator or this person might be related to the perpetrator (Jobling and Gill). The field evolved in the 1980s with the discovery of Minisatellites, lines of repetitive DNA that don’t encode proteins. Minisatellite patterns in DNA create what we know today as the DNA fingerprint, and it has a much higher accuracy rate than previous methods (Augustyn et al.). Around the same time, a breakthrough for victims of sexual assault was discovered. In the case of assault, bodily fluids of both the victim and the assaulter can get mixed. A process called differential lysis was created which could selectively increase the concentration of sperm in a fluid sample thereby allowing for accurate DNA testing (Jobling and Gill). Forensics evolved to use single-locus probe testing after several years because of its ease of interpretation. It looked at specific minisatellites that had high variability between subjects. This was the first DNA-based method to be used in a criminal investigation. Two murder homicides from several years apart were connected using DNA evidence. The evidence was then used to exonerate an innocent man, and the guilty party was found when he tried to evade mandatory DNA testing for all men in the small town. His guilt was then reinforced when the DNA profiles matched, and he gave a confession (Jobling and Gill). Finding DNA at a crime scene doesn’t guarantee that you’ll find a murderer. There are issues with non-pure samples and limited samples that make DNA work difficult, and accreditation of facilities and new techniques and take time (Jobling and Gill).  

Subjectivity of DNA Interpretation:

In a 2009 publication, the National Academy of Science discusses the possibility for subjective influence in lab based forensics. The interpretation bias happens in complex cases where, for example, there could be a mixture of DNA. A study published in 2011 looked specifically at this issue. A gang rape happened in Georgia, and the mixture in DNA from the case was used to prosecute one suspect after another suspect took a plea bargain to testify against him. With DNA mixtures, there are three possible conclusions: suspect excluded, suspect cannot be excluded, and inconclusive. If the suspect is excluded, it means that there’s little to no possibility that his DNA is part of the sample. If the suspect cannot be excluded, it means that there’s a possibility that his DNA is part of the sample. In the trial, the DNA examiners who knew the context of the case concluded that the suspect being prosecuted could not be excluded. The 2011 study gave the DNA evidence from this case and the DNA profiles of the suspects to 17 forensic examiners. These examiners had no context of the case, and they all worked independently. Of the 17, only 1 came to the same conclusion (suspect cannot be excluded) as the examiners who knew the context of the case. Twelve of the 17 concluded that the suspect who was prosecuted and convicted had no relation to the DNA found in the sample. Not only does this show that subjectivity occurs due to the context of the case, but the 17 examiners came up with different findings based on their past experiences meaning that not all DNA analysis is objective. Some organizations like the Scientific Working Group on DNA Analysis Methods say that quantitative statistical evidence should be presented with every categorical conclusion, but the US doesn’t require this (Dror and Hampikian).

False Positives:

There are two categories that cause wrongful identification in a DNA report: coincidental matches and false positives. Coincidental matches are DNA matches between two unrelated people. The probability of these matches is about 1 to 500,000 for white individuals and about 1 to 350,000 for black individuals. This small probability of coincidental matches makes people feel confident in DNA evidence. False positives, on the other hand, are matches between DNA and test DNA that result from issues in the forensics lab. There have been multiple cases of forensics labs accidentally switching victim and suspected rapist DNA which lead to convictions that were later overturned when the lab realized the error. There are also cases of misreading or misunderstanding a sample. In a case from 1993, a man was convicted of rape because someone interpreted a mixed sample of victim and perpetrator DNA as an individual sample. The conviction was again overturned. To prevent false convictions, retesting DNA is allowed, but it’s not an efficient solution. Many people are pushing for statistical information on the probability of false positives, so that the jurors can make accurate judgements based on DNA evidence (Thomas et al.).  

Conclusion:

DNA analysis is a useful tool for the criminal justice system, but subjectivity can be an issue in forensic testing. To combat wrongful convictions, there are organizations like The Innocence Project who use DNA testing to free the innocent, but reformed forensic testing standards should be put in place to prevent subjectivity and to ensure juries are correctly informed during trials. https://www.innocenceproject.org/    

Citation:

Augustyn , Adam, et al. “DNA Finerprinting.” Encyclopedia Britannica , 26 Apr. 2018, www.britannica.com/science/DNA-fingerprinting#ref153186. Dror, Itiel E., and Greg Hampikian. “Subjectivity and Bias in Forensic DNA Mixture Interpretation.” Science & Justice, vol. 51, no. 4, 2011, pp. 204–208., doi:10.1016/j.scijus.2011.08.004. Jobling, Mark A., and Peter Gill. “Encoded Evidence: DNA in Forensic Analysis.” Nature Reviews: Genetics, vol. 5, no. 10, Oct. 2004, pp. 739–751., doi:10.1038/nrg1455. Thompson, William C, et al. “How the Probability of a False Positive Affects the Value of DNA Evidence.” Journal of Forensic Sciences, vol. 48, no. 1, Jan. 2003, pp. 1–8., doi:10.1520/jfs2001171.